“Enough is enough! I’ve had it with these motherfucking snakes on this motherfucking plane!”

Nelville Flynn (Samuel L. Jackson) and Sean Jones (Nathan Phillips), who are FBI agents, escort John Saunders (Mark Houghton),
a former Mafia member, to testify in a highly publicized case. In the
course of a flight between Hawaii and California, an assassin pays
airport security to sneak a time-release crate of 400 snakes of various sizes on board in the hope of killing the witness.

The story apparently has gone through revisions, as is often the
case with feature films. In at least one existing draft of the
screenplay, the Sean Jones character is a 17-year-old witness to the
murder by mob boss Edward Kim. Sean is the one being transported by
agents. The character of John Sanders — spelling cq in this draft –
is an FBI agent, not a witness. He is Flynn's superior, who happens to
be afraid of snakes.

Snake on a Plane has become quite the internet phenonemon. Many people are blogging it, writing songs, parody films, a board game and so forth. 

I highly recommend this parody of a casting to SoaP. Dave Coyne brilliantly imitates Cristopher Walken, Robert DeNiro, Jack Nicholson and Joe Pesci.